Disk Insertion error on bootup

I'm running leopard 10.5.1 and almost everytime I boot up I get an error box saying "Disk Insertion" asking me to click ok or ignore. The only other thing acting strange on my puter is disk utility which locks up and wont detect my hard drive. I got around disk utility by using terminal to run permissions which ran but did not fix the Disk Insertion error. Anyone else got this?

Jason