On one hand, I almost never delete apps and I probably wouldn't bother trying to find and delete any "leftover" files.
...but on the other, I do a clean install of my Mac every couple of years. Is this more or less work? I'm not entirely sure now. 😅
(to be fair, I've reached the point where the only software I install is Pixelmator Pro, some browsers, Xcode and some other software development stuff, and a bunch of command line apps in the Terminal)