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I do, I use them on my eMac and the lonely command key in my iBook, I prefer to work as most as possible with the keyboard and those keys come handy, command O, P, K, selecting tabs in Safari, menu bar, dock ... yes I do...
 
I would think mouse-using left-handed people would use them from time to time.

I use the Command, but never the others. For all I care, the Option, Control, and Shift on the right side could be replaced with arrow keys.

If only I had a right "mouse" button integrated into my PowerBook, I would probably never use either Control key.

And I wish the Caps Lock key didn't exist at all. I spend half my day deleting stuff I SHOUTED by accident.
 
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