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You need iTunes 10.5 beta 4 to sync a device that's running iOS 5 beta 4 and for wireless sync to work properly (if you're running Windows)
 
I am guessing by your question you are new iOS beta. Beware that there are plently of bugs. For instance, beta 4 will empty your photo albums. Be sure to backup your phone first and read the patch notes. Also, I'd recommend making a copy of the backup in case something screws up and the backup gets overwritten. If any of the makes you nervous, you should wait.
 
you'll be able to upgrade from beta 3 to beta 4 via OTA but when you'll need to sync it you must have the itunes 10.5 beta 4
 
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