I'd use InsomniaX and would really only be leaving it on so I can stream iTunes without having to always leave the screen open. Just got my first MBP, so I'm use to always letting my iMac run except when sleeping/while at work. I'm hoping to do the same with my MBP. It would be on from about 5pm-11pm Mon-Fri and around 10am - 1am Sat/Sun.