I prefer Chrome. When I do use Safari, I use an ad blocker. To me, using the internet without an ad blocker is like stumbling around in a dark alley hoping to find something useful under heaps of garbage and manure. I'm appalled at how many popups, popunders, moving, noisy, distracting ads come up when I use a "naked" browser.
Using the internet without blockers is also comparatively unsafe. The few viable malware attacks in OS X almost all rely on weaknesses in Safari.