Disadvantages
Limited viewing angle, causing color, saturation, contrast and brightness to vary, even within the intended viewing angle, by variations in posture.
Bleeding and uneven backlighting in some monitors, causing brightness distortion, especially toward the edges.
Smearing and ghosting artifacts caused by slow response times (>8 ms) and "sample and hold" operation.
Only one native resolution. Displaying resolutions either requires a video scaler, lowering perceptual quality, or display at 1:1 pixel mapping, in which images will be physically too large or won't fill the whole screen.
Fixed bit depth, many cheaper LCDs are only able to display 262,000 colors. 8-bit S-IPS panels can display 16 million colors and have significantly better black level, but are expensive and have slower response time.
Low bit depth results in images with unnatural or excessive contrast.
Input lag
Dead or stuck pixels may occur during manufacturing or through use.
In a constant-on situation, thermalization may occur, which is when only part of the screen has overheated and looks discolored compared to the rest of the screen.
Not all LCDs are designed to allow easy replacement of the backlight.
Cannot be used with light guns/pens.
Loss of contrast in high temperature environments.
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