Drag and Drop Problem

I have an issue in Lion where when dragging something, that icon/image gets stuck as the cursor. While it's stuck to the cursor, nothing can be done with the mouse. The only way to remedy it is to quit whatever program you're running, or if in the OS proper relaunching the Finder. I've found it does not occur in Safe-Mode, so perhaps it is something secondary to the OS itself which is causing this..?

Any input would be appreciated.