I tend to drive with my left hand...one thing I've noticed is every time I make a turn or any movement on the steering wheel, my watch turns on, and when I finish the turn it goes off...over, and over and over.
You should drive with both hands on the wheel where possible. This will help you to remain in full control of the vehicle at all times.

It's not like I'm driving in my car all day but I'm thinking it would have an impact on the battery life during daily commutes.
I had two 3+ hour drive's this weekend using the iPhone for navigation. Turn instructions are relayed to the watch which means you get haptic feedback and the screen displays the required manoeuvre. The impact on battery life is negligible.
The watch did tell me to stand up for a minute after an hour of driving.
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