Well,
I have three monitors and they all can't run on the same card and it runs very smooth for me.
I have 2x23"ACDs on the 8800 32EFI and a Cintiq 12" on the 7300GT. All this with out a hitch.
I am also testing the same config with the ATI 2600HD, where I have the Cintiq connected and after a fresh install of Leopard it works without a problem. I did have some earlier problems with Leopard after migrating from my MBP to the MP with Tiger and then upgrading.
I hope this helps.
JM