duplicate fonts question

Hello, all.
I've been having problems with Logic Pro ever since the 10.5.2 update (and other updates that appeared at the same time).
Some folks on the Apple discussion forums thought that font issues may be to blame. Most, however, still have problems after resolving their font problems.
I went into Font Book anyway to see if there was anything I could clean up. I've already done the "resolve duplicates" thing with fonts that had the dot by their name.
This time, I selected all fonts and validated them.
I ended up with 42 'minor problems'. After going through each one to see what the problem is, they all said it was a duplicate font issue.
Now, I'm not the type to go deleting fonts willie-nillie. When I went back into Font Book, each of the problem fonts did indeed have duplicates when I folded down the little triangle guy. All of the duplicates were grayed out with the word OFF next to them.
Should I delete these guys that are already off and disabled? Would that actually have any benefit, or is the fact that Font Book turn them OFF the proper solution?
Thanks!