My eGPU Setup: Late 2012 Mac Mini - iGPU Sonnet SEL Thunderbolt Expansion Chassis AMFELTEC GPU CLUSTER 2x ASUS GTX 780 1x MSI GTX 580 RM1000 Ok, So I've spent the last 3 days getting this together... Ive come to the conclusion that no OS X machine can handle 5 GPU's. I tried multiple configurations of GPU's with multiple methods with drivers no drivers 10.8 / 10.9 / 10.10 Ive tested 5 GPU's on a 2008 & 2010 Mac Pro - Got 4 running really well. Mac Mini - Max 3 due to intel 4000 Macbook Pro - Max 2 due to intel 3000 & 6770m Macbook Air - Max 3 due to intel 3000 Although Jose got 2 Titan Z's working with his iGPU its blowing my mind to think that it is and its not.... Im not sure about anyone else but 10.10.2 i could NOT get anything going not even a single card. Kept coming up as DISPLAY in graphics section... Also maybe I'm just the retard but also couldn't modify the driver to work on 10.10.1, But the default drivers perform great. Sleep and Wake up are normal... Have repeatedly shut down and turned on the system without disconnecting the connection and have had no problem at all... Although there is some Hiccups.... 1. Cant get display through my mDP on the Sonnet - UNLESS i plug a HDMI directly into the Mac... But then the resolution is locked at 1080p WEIRD???? 2. If someone has the modified driver for 10.10.1 please share would like to know if it was just my retarded self that can't modify anything or the way of set it up 3. IT HAS KILLED MY AUDIO.... please see attached image. If someone can help??? Ive done a PRAM & SMC reset and still nothing, I get boot chimes. It makes me wonder on the limit of the Mac Pro 6,1 is it limited to 2 eGPU... My Opinion on getting this going (from my experience): Get yourself TextWrangler & Latest CUDA drivers Modify the 3 KEXT file /System/Library/Extensions/NVDAStartup.kext/Contents/Info.plist /System/Library/Extensions/IONDRVSupport.kext/Info.plist /System/Library/Extensions/AppleHDA.kext/Contents/PlugIns/AppleHDAController.kext/Contents/Info.plist Shut down your system. Plug Thunderbolt in and turn PSU on. Turn on your Mac. and thats it.