Can't quite figure this one out. In OS X 10.11.1: after booting into safe mode, then rebooting normal, App Memory goes up permanently. Before safe mode: App Memory: 521.2 MB Wired Memory: 470.3 MB Then, Boot into safe mode, all subsequent reboots yield: App Memory: 2.67 GB Wired Memory: 525.1 MB Also, in Activity Viewer, seems like all process jumped up 10 MBs, which could explain the App Memory going up, but I still can't figure out why. Doing a Command R and "reinstall of OS X" puts the memory usage back to what it was before booting into safe mode. That takes a while however and it seems like there should be an easier way to put the memory usage back to normal. With prior OS X versions, I used to boot into safe mode occasionally to clear out caches. This did fix the occasional problem. But now, I am scared of safe mode.