Good luck. From what I understand many scanning features of "older" multifunction machines are "broken" in leopard. Epson's a good company and they usually keep up with things as far as drivers go. So just make sure you have the latest ones.
I was just able to get my HP Photosmart 7550 to work with Leopard. It's not a multifunction, but also wasn't supported by HP any longer, and there was supposedly no leopard drivers for it. I found Linux ones that work beautifully (better than the HP ones ever did on 10.3 or 10.4 in fact) and best of all they are only 11mb to install...instead of HP's BLOATED 150+ mb install.
I really don't get why companies don't update drivers. It just creates consumer waste because people throw them away and buy new ones, but i guess thats what they really care about, making money off new machines.