I would think so, but it might be advisable to check by sending an email first, as IIRC, there's been some stating they've been having issues with eSATA cards that work in Macs (previous models).
What I'm not sure of, is if those that had issues used slot 4 or not, as that one is meant to work with Apple's RAID card, as the data is sent via traces on the logic board rather than a cable. To do this, the RAID card has to be able to switch the logic board controller "OFF" for those ports. There could be some sort of interaction going on (though there shouldn't be; but nothing's usually problem free these days). 🙄 😉