After a couple days of frustration (not alone it seems) I was able to get my work exchange account to sync with the iPhone (mail, contacts, calendar). I am supremely impressed with how it works!!!!! Changes (eg deleting an email from either my work account or the iPhone) are reflected so fast it's shocking!!! I have also been able to get my mobileme account to sync with my iPhone and my wife's so we can edit various personal/family calendar's and have them adjust to the other devices/computers very quickly. The overall interface and opportunities are just fantastic... Apple rocks... the couple days of growing pains are nothing compared to the final product!!! My only minor gripe now... unable to set separate signatures... so for now have my more formal work sig but would be nice to have a signature attached to each email account.