In my personal uneducated opinion...
If you are taking the drive with you on a frequent basis, IMO the drive for you is a Samsung T5. HDDs all lack substantial shock resistance, where as SSDs can withstand tremendous impacts. Silicon Power offered (and still may offer) several 2.5-inch HDD enclosures that have reasonable impact resistance, but even these has their limits (especially in regards to impacts occurring when the drive is running, which is pretty common and happens to even the most careful of users.) For very mobile users, I find it increasingly difficult to justify HDDs, personally, because of the track record of reliability, speed, and impact resistance that mobile SSDs have generated.
I mainly use HGST 3.5-inch enterprise drives with relatively well-known and low failure rates. Like any and all HDDs, they sometimes fail early, and without warning. IMO, more important than brand is to keep multiple copies of important files you do not wish to lose. Two is good, three+ is better, preferably in two different physical locations, to provide optimal protection against data loss.
With 2.5-inch HDDs, there is arguably less data regarding failure rates available than what is already a limited amount of data on 3.5-inch drives (a huge portion of which comes from two sources, only one of which names brands, and both of which use the drives in a different way than most consumers.) With 2.5-inch drives, I try to avoid most pre-configured externals because, A) I have concerns regarding the quality of the drive being used in pre-configured externals being of lower quality/tier than the internal 2.5-inch drives the same company offers (I feel this way especially in regards to WD and Seagate externals), B) I dislike how many of these drives use a soldered SATA bridge, which adds a completely unnecessary layer of complexity to recovering files and using the drive in the event that the bridge fails or the enclosure-side port becomes damaged (something quite common with some pre-USB-C enclosure-side connectors), and C) purchasing the enclosure + drive separately often does not cost much (or anything) additional than a prebuilt, and the drive may have two or more times the warranty of a pre-built model.