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Every USB enclosure I've ever seen has either required, in addition to the USB data connection, a second USB connector for power or some other power connector (power brick, etc).

I just bought a western digital external 2.5" drive and it comes with only 1 USB connection. The drive is low power enough that it can run from just this on any USB 2.0 port.
 
I just bought a western digital external 2.5" drive and it comes with only 1 USB connection. The drive is low power enough that it can run from just this on any USB 2.0 port.

i have one as well
 
I would recommend a combination of USB and Firewire. Having Firewire gives you the ability to be able to boot from the hard drive, which I have done once.

I can boot from a USB WD external HD with no problems. Intel Macs can boot from USB HDs.
 
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