I don't think Apple has a way of telling, the media is all the same, the only difference is the piece of paper that comes in the box is different.
jeff -- awesome, i'd go for it. i COULD have used my EDU discount on the leopard family pack but i ended up using amazon since shipping is free and there's no tax -- it's also $10 cheaper out the gate.
no, apple probably wouldnt be able to tell. idk, someone might think i'm one of those people who think apple is doing me a service by releasing leopard, and that i 'wouldnt dare steal from the mighty apple' but i really just feel bad pirating any software... osx is no exception.