Id say flashlock would be a safe bet, I am using it with my firefox across all machines. Yeah its a few extra clicks if you're wanting to view content but the stress relief on the the system it is worth it.
You can also get flashblock for google chrome. But you have to enable extensions on the OSX version. Unless this has been added to the new upate without having to modify?
Correction:- I looked in Activity Monitor at the Flash process and windowed this movie used 38%, pretty constant. I couldn't see Activity Monitor when the video was full screen!
This is with Flash 10.0 r42, that's about 1/2 the CPU load of Flash 9. I still always use clicktoflash or flashblock