Okay... your house is on fire. All the people and pets are out safe. You can run back in and save five things. A water hose does not count 
1) The folder of drawings and handmade gifts that my kids have given me
2) small teddy bear I had as an infant.
3) my college ring (I never wear it, so it would have to be saved)
4) G.I. Joe I had as a kid in the early 1970s
5) my grandfather's hat
honorable mentions (with me, there are always honorable mentions)
tool collection from back when I worked as a mechanic (probably the only replaceable things I would consider saving)
my Russian watch
The Hawaiian shirt I wore on the first date I had with my wife
1) The folder of drawings and handmade gifts that my kids have given me
2) small teddy bear I had as an infant.
3) my college ring (I never wear it, so it would have to be saved)
4) G.I. Joe I had as a kid in the early 1970s
5) my grandfather's hat
honorable mentions (with me, there are always honorable mentions)
tool collection from back when I worked as a mechanic (probably the only replaceable things I would consider saving)
my Russian watch
The Hawaiian shirt I wore on the first date I had with my wife