I'm no genius so be nice
Hey everyone, just thought i would chime in on this lively debate
and honestly, something i found when using my signature laptop, instead of upgrading from 4GB to 8GB i decided to upgrade my HDD to an SSD, and for some reason i had much less stalls in my programs and what not (considering i'm a powerhouse multi-tasker) and many of Apple's Native Apps have become such memory-hogs (i'm looking at Safari and iTunes Beta 10.5) but i don't know what it is, but when i'm very low on RAM (high Active and Inactive), i rarely notice any sluggishness, plus encoding, downloading, and iTunes access times are considerably higher (i know this is, i think, due to much faster read and write from the SSD)... try upgrading to an SSD lol, best thing i did to my laptop 
Hey everyone, just thought i would chime in on this lively debate