Everything just feels harder to do on iPad. Navigating Files requires double clicking on folders now, SlideOver is sorely missed, Preview app just gets in the way (deleting it means PDF files open in Books instead, but what was wrong with it opening in Files?), and with two apps in the new split view, you can no longer close one of the apps by dragging the divider to the edge of the screen. One app has to be made full screen or the other one closed. With an external monitor, the snappy window sizes made making multiple apps the same size easy. Per-pixel sizing, especially with the bouncy UI, is more challenging, though Beta 4 will auto-size apps to line up as long as you get them close first.
Some people like the new cursor. I’m still mixed. I kinda liked how the old one would snap to app icons and buttons (at least with a trackpad). Of course, the interface is still too buggy to get a solid feel on the new cursor.