I presume you mean that you want OS X to store some data on another drive because your SSD is filling up.
Aliases aren't good enough. There is a Unix equivalent called Symbolic links, and it is possible to move some folders that OS X expects to be in a certain place and move them, leaving a sym link in its place that points to the new location.
However, there can be problems with this method, and OS X can be a bit temperamental about it.
.or merge your SSD and an HDD into a Fusion Drive, of course!