The only real negative I can come up with is the fact that there are some missions later in the game that are going to be VERY VERY difficult to get past. For instance, there are some racing missions where if you even bump into something like a street light, etc.., that you will lose the race. How I am going to be able to do a race and not hit anything I have no idea. I mean, some of the later missions were difficult with a Playstation controller, can only imagine what it will be like with the touchscreen.
Has anyone figured out how to fire a gun out the window of a car? I've only got the pistol so far.