I am completely stumped and hoping someone might have a solution, or suggestion for this. I've been using Handbrake to encode DVD material for playing on ipad. I have tried every single preset; Universal, ipad imports from other sites, Apple TV, etc. Every single encode has a delay between the audio and video of several milliseconds when played in itunes and synced to idevices. It's not enough for my grandmother to notice - but I notice and it never happened with previous encodes using handbrake. I've played the videos in VLC player, mplayer, half a dozen others - no audio/video issues. The VLC player on ipad plays the videos with perfect audio/video sync. Only in itunes and idevices does this absolutely infuriating delay occur. I've read on some other forums that people are having similar problems with their ipod touches and iphones and am wondering if it is a bug in itunes or is the ipad simply not able to handle the encoding. It can't be that, because the videos downloaded from itunes, both standard def and hd, are playing perfectly on it. I'll add that I'm still on PowerPc iMac g5, but I can't see that it's a processor problem, because this never happened before. Any help would be appreciated and let me know if anyone else is having similar issues.