I've played many many hours of games on a Windows install on my 2009 15" MBP in clamshell and have never had any issue. The only thing I've noticed is that over time the keys have become more....well, "seasoned" is the only way I could describe it. Though it could just have to do with normal wear, they don't feel like keys on other peoples computers; I suppose this is because they've "cooked" at 85-90C for a few hundred hours. Fortunately, I like the way they feel and can't stand using other peoples' machines. So, while gaming in clamshell will have absolutely no effect on your internal hardware, it could have a peripheral effect on your keys.