Whew, this thread has come full circle
For a home setup, I fall back to my earlier recommendation for a four drive setup. Two drives configured in RAID1 as your primary storage set, 2 drives in RAID0 as the backup data set. I've operated my media library this way for years. If a drive in the primary set goes out you can continue to operate until you get around to rebuilding the mirrored set.
Right, but an array like that considerably limits the capacity of the entire system. With something like you've proposed I'd be stuck in the 4 TB (until we have bigger and cheaper disks).
Since you want a single enclosure, take a look at http://eshop.macsales.com/item/OWC/M3QX2KIT0GB/. You can operate the drives in various configurations from one enclosure. I used OWC for a while when I used FW800, their stuff was always reliable for me.
It was one of the options that I was seriously considering. However, since they seem to have problems with the WD Reds, I'd prefer to buy the Mobius 5-bay.
With an enclosure like that, you can use the built in hardware RAID or OS X software RAID to set two drives as your primary mirrored set and two drives as your striped backup set.
Ok, that's a question that I've always had. Can you set multiple drives as a RAID X, other drives as RAID Y, and others as RAID Z, all in the same enclosure using software tools?
Although RAID of any kind (other than RAID0 for aggregating storage space) is overkill for home use, IMO, RAID5 is definitely unnecessary unless you simply want the "thrill" of toying with it. Set up a reliable backup system like Time Machine first, then tinker with alternative primary storage options like RAID5 if you are so inclined.
Truth is I don't want to toy with anything
Why did I chose RAID5? Because in terms of redundancy and capacity it's definitely the most balanced option. I don't sacrifice too much space and still I can get things working again if some drive fails. But again, is not that I'm so inclined to one RAID or another, it's just that it looks like the best alternative in my amateur vision.
I insist though. If your think RAID it's overkill, I welcome more suggestions.