I know this is something a lot of people have experienced, but I feel like I have tried just about everything I can think of, without any success. Over the past few weeks, my AppleTV have been losing its connection with iTunes. After working fine for a few days, iTunes will no longer show the in the Devices list on the sidebar or list it under AppleTV in preferences. The only thing that seems to make it work again is to factory restore or set up the iTunes library again, both of which require re-syncing many gigabytes of data, which takes hours. These are the things I have tried: 1. Factory restored AppleTV. 2. Set up as a new iTunes library instead of complete restore. 3. Rebooted AppleTV. 4. Reset router. 5. Set up AppleTV to connect to network via Ethernet instead of WiFi. 6. Turned off/unplugged/removed the cordless phone that was near my iMac, thinking maybe there was some kind of wireless interference causing this. 7. Set up iMac to connect to network via Ethernet instead of WiFi. 8. Factory reset router and set up network all over again from scratch. 9. Exchanged AppleTV for a new (well, refurbed) AppleTV at Apple Store after discussing this several times on the phone with Apple support. 10. Uninstalled iTunes, including all preferences and everything except for content and reinstalled. After each step, factory restoring the AppleTV will let iTunes detect it once more for a period of time - sometimes hours, sometimes days. But eventually iTunes stops finding the AppleTV. I can't find rhyme or reason as to why this happens. This actually happened to me a few months ago, but a single factory restore fixed it and it's been fine ever since until the past couple of weeks. I am out of ideas. I didn't really think it was a hardware problem with the AppleTV, but I exchanged it because I have no other way of reformatting/reinstalling an AppleTV. But of course, that didn't fix this either. My setup is an AppleTV running the latest firmware, a late 2009 21" iMac running Snow Leopard 10.6.3 (all updates installed), and an AirPort Extreme as my router.