If you're looking for speakers I highly recommend JM Lab. They're are made by Focal. Focal makes drivers and crossovers for hi-fi companies such as Wilson Audio (regarded as one of the finest speakers). Focal decided to then start making their own speakers. I have their entry level, but I've heard them all, and I can say they are amazing. Especially for the money. I went with the Chorus 705's since I only had room right now for bookshelfs. They'll eventually be the rear channel speakers when I have room.
http://www.focal.tm.fr/
Another good choice I would recommend is Vienna Acoustics, but you can get a better deal but same sonic performance from JM Lab.
I realize you have Bose, and you got flamed for it, and most high end audio guys will give you grief for them. I won't give you grief, but I'll explain quickly why hi-fi guys don't like Bose, Bose plays loud, they're bright, and they're boomy. So people buy them for home theater, but if you're looking for listening to just music in a stereo arrangement, I do not recommend Bose at all. I used to sell B&W and other high end audio equipment, and I would see other people buy Bose and then come back to me and say it sounds nothing like we had to offer.
Now if you're looking at hi-fi equipment, and not the speakers. I recommend Integra (high end division of Onkyo), Rotel, MacIntosh, or Mark Levinson.
Subwoofers - I always liked Velodyne personally.
Interconnects - I use StraightWire. Don't go the Monster route, Noel Lee is a master at marketing. StraightWire makes the wire by hand, and they also make and do the wiring for major studios and for other high-end audio companies.
http://straightwire.com/
Hope that helps. I recommend you bring some CD's that you're very familiar with, and spend about a minute or two listening to them by yourself in the room of a true high end shop. Do not, I repeat, DO NOT have the sales person switch back and forth between speakers while you listen. You will always pick out the worst speaker, and the reason is because it's bright and/or boomy and it sticks out in your head. You'll then take them home, and you'll be disappointed. I used to work for a high-end audio store, and used to design whole house audio/video for clients. You have to listen, and pick what you like. It took me close to 1.5 years to find the speakers I wanted after a lot of listening. If you're looking for control systems I recommend Crestron, and Lutron for lighting.
I personally use run the following (not much, but room and budget was and still limited):
JM Lab Chorus 705
Onkyo TX-DS484 Home Theater Receiver
Onkyo DV-CP702 6 Disc DVD Player
iPod Dock
AudioQuest Mini-Plug Mini Series 3 from iPod Dock to Onkyo
StraightWire Maestro II
For Video StraightWire Component Video Silver Link II