I'd say if you A-B'd lossless vs. lossy with just about anyone, telling them what to pay attention for (ex. the cymbals), they'd notice, especially at the bitrate iTMS uses. Sure some people can notice the difference no matter what it is they're listening too, even on stuff that actually compresses well, but there are a few things that are just plain obvious once you stop and listen. I'm all for quality. Now they just have to work on the DRM issue. I'd buy album after album from iTunes if they'd do lossless and no DRM. Heck, I could compromise a little, purchase a lossless album, burn it, re-import it DRM-free. Right now it's just the ocational track. I hardly ever use it without giftcard credit.