I appreciate the replies, but maybe I should have given a little more history.
I've had an iphone 2g for 2 years and I've done the same thing every day and never had a problem. Battery would drain to about 80-85% sitting in the car.
After I got the 3GS I did the same thing and had no problems for a week. The last 2 days I've had the problem. I thought yesterday was a fluke, turned the phone off, charged it up last night, and the same thing happened today. Nothing has changed except for updated apps (no new apps).
Car is in a cool garage so it doesn't get hot.
Phone has 5 bars on 3g.
The past two days the battery has drained and the phone is noticeably warm. Much warmer than the car.
The phone is obviously doing something to waste the battery and get warm. If my 2g lasted 2 years with no problems, why is the 3GS having problems with the same settings? I doubt anyone has the answer, but just wondering if people have seen something similar.