I just lost my drive :-(
I use SuperDuper and run it to an external usb disk the same size as my internal drive.
The bad news is that I got lazy and haven't backed up since April.
The good news is that I recovered a lot of stuff from other sources (sd cards from the camera.
So I ran to Fry's and got a 200G drive and started using that just to be able to get work done. I then ordered a 250G from NewEgg and SuperDupered the 200G -> 250G when it arrived.
It's so stinking easy that it's scary. I now backup the following:
1: External 250G --> 2 times a week, complete image
2: 8G USB stick --> Just the parallels image (which is 7.3G, made to fit on a 8G flash)
3: Portable 250G --> once a week
I also write all new pictures, etc to 2 other machines as I load/edit them.
It seems like a lot of work but lost data is sad..