Well sequential speeds aren't going to help you here (unless you are pausing the VM alot since it copies the contents back to ram when being unpaused) USB is not known for it's large queue depths so OS performance from these drives will be slow no matter what due to the interface. Slow is relative but booting Mac OSX or Windows nativly from a USB drive is surprising fine so doing VM work wont suffer too bad unless you have multiples on the same drive.
I use a patriot USB 3 256GB drive and I haven't got annoyed by the speed yet.