I'm pretty solid with Windows, since it's what I use more often than not. I'd say your advice is sound, though a little overkill in places. From my experiences, I'd pare some things down a bit.
1. Don't use IE? Sound advice. Even though IE10 and 11 are pretty solid these days, they still tend to attract weird plugins and add-ons you don't want. Use Chrome or Firefox instead.
2. Speaking of add-ons, these tend to come in with free trials for programs you get off the internet. You'll go in to install something, and see a bunch of checkboxes with "INSTALL ASK TOOLBAR NOW" or "MAKE BLAH YOUR HOMEPAGE". Because of these very annoying people doing very annoying things, it's best to read through every window that pops up during an install process.
3. Antivirus? I'd use Microsoft Security Essentials, which comes standard with Windows 8. It doesn't harass the hell out of you, and does its job well. Drive by viruses are rare things in Windows these days, so this isn't nearly as big of a deal as it used to be. But still, it's nice to have one around just in case.
4. Malwarebytes Antimalware is also a good fallback option. I tend to run it once every other month, along with...
5. CCleaner. Like your Tuneup Utility, but much, much lighter. Windows does have a tendency to collect some cruft after awhile. It's not terrible, but sometimes you'll want to clean your caches. This program does a great job without getting in the way.
6. The Registry. Don't worry about it. I know it has a bad reputation around here, maybe deservedly so, but I've never ever ever once had a problem with it. If you still feel an absolute driving need to fix it, CCleaner does a good job of it, but I'd say leave it alone. Especially if you...
7. Use Revo Uninstaller. Which basically does what all Windows installers should do, keeps track of all the changes a program makes, to the registry, the folders, and all, and gets rid of them entirely.
8. Page File! Here's a complicated one. Since time immemorial, I've always set my page file to a fixed size on its own separate partition. I don't even know if this nets any advantages anymore (it's probably less important on an SSD equipped system), but I do it.
Yeah, we've probably scared this guy away from getting a Windows PC entirely now.
I've used it for years, and problems are exceedingly rare for me. Everything runs smooth, stable, and nicely, sometimes even smoother than it's Mac equivalent.
...but it is occasionally fiddly, and it's this fiddliness that someone moving from a Mac to a PC will likely have a hard time coming to terms with. OSX never ever seems to get in your way (except when it does), while Windows does require you to sit it aside to wipe it's nose and clean out its eye boogers every once in awhile.
edit: 9. If you see anything with McAfee or Norton on your brand new computer, kill it. Don't even give it a second thought. Pull the trigger, and kill it until its dead. A good number of problems I've seen people experience with Windows come directly from their overzealous, resource hogging, cure worse than the disease virus scanners and firewalls.