Computing is a bit more complex than "faster and slower" – It is actually very task dependant. Different things require different things from the system. What will you mostly be doing? – And are you running out of RAM (Check Activity Monitor). If you are, anything with more RAM will boost your system's performance with what you do. Almost regardless of other specs. Once you run out of memory, the performance drop off is steep.
Only thing the fewer amount of pixels will impact (almost anyway), is GPU performance. Not CPU or anything else. Well, again, for the most part.