I've plugged my iPhone into my computer probably 2-3 times since I got my 4S about a year and a half ago.
I've started plugging in for updates since I get a fresh copy of iOS not just a patch. App updating I do via wifi, generally because the App Store is to slow on 3G.
I liked to keep it synced to my computer for backups and I do not trust iCloud not to be completely useless, the backup on my computer does a much better job. The wall charger is used the most, 90% of the time or more when just charging.