How to run .iso files (for pc) using Crossover?

I've been raking all over the internet to find a solution, but I can't seem to do it.

I wouldn't say I'm new to this, but I'm completely lost: How do I run .iso files on mac that are intended for pc?

When I say that, I mean the .iso seems to be mounted correctly on my mac, as in I can see it on my finder and desktop. It's just that when I open it, it doesn't run the game, but shows its contents like autorun.exe and setup.exe and other little folders.

I've been trying to use Wine in Terminal and Crossover, but neither seems to be working.

I've tried using Crossover Software Installer and got the setup process running, but at the end of the setup, it suddenly showed an error, which said 'The program Installer.exe has encountered a serious problem and needs to close.' and 'This can be caused by a program or a deficiency in Wine.'

Afterwards I've tried reinstalling the same way, which just takes up more space in my hard drive without results. When I ran autorun.exe afterwards, it would show me the 'Play game' screen, and when I pressed it, it would seem to be loading correctly then just end up with a black screen. Could it be a graphic driver issue?

Again, I'm not even sure if I'm doing this correctly, as I never fully understood Wine. I would really appreciate it if someone could point me in the right direction in this.

I am using Mac OS X, version 10.6.6, 2.26 GHz Intel Core 2 Duo and CrossOver Professional version 9.0.1.