Well, first thing out of the box it's an empty phone so first thing we would normally do is plug it in the computer, set it up and sync our stuff. For me personally, as it plugs in the computer, after my syncing is done, I reboot it by replugging it back in the computer and just let it fully charge. Then out and about, I just let it drain to zero. Then fully charge it again and just go on with my daily use. Some articles say it takes a few more full cycles for the battery to be fully conditioned but I wouldn't worry much about it as long as you're using it a lot. After about a week or so, I'll do another full drain and charge again. Then after that, I do this recalibrating about monthly or when I'm lazy, every 2/3 months.