Where possible it's better to use Thunderbolt for RAID arrays. It's not a matter of performance but one of reliability and ease of configuration, e.g, you can string Thunderbolt drives together.
That said, we don't know for sure your issue is caused by USB. I have many RAID arrays, mostly Thunderbolt but a few USB 3 models. In general they both work OK, but I've had more spontaneous disconnects from the USB models (though not a large number).
As
filmak stated, check your USB cable, make sure it's the original one and it's not damaged or loose. Try a different USB port on the iMac. Don't use a USB cable of different design or length.
Another possible cause is an intermittent or emerging hard drive failure. I had a two RAID-0 arrays fail last week, one an 8TB G-RAID and the other a 16TB OWC Elite Pro Dual (Thunderbolt version). In both cases a single drive in the RAID-0 array failed. The G-RAID was only a few months old, so this can happen on new drives. The OWC was about 18 months old. Neither of manifested as a disconnect. The G-RAID was under SoftRAID control, which reported an emerging problem due to high retry counts. The OWC drive was using hardware RAID and it just failed, which crashed macOS, even though it was only a Time Machine drive. In both cases I replaced both drives in each RAID on the principle that if one HDD fails the other is more likely to fail, sometimes called "
sibling mortality" syndrome.
It's probably a good idea to reformat the drive and run a full surface validation test on it. There are several utilities which can do this; I've used
Scannerz:
http://scsc-online.com/Scannerz.html
DiskTestR:
https://diglloydtools.com/disktester.html
SoftRAID:
https://www.softraid.com
Micromat has a S.M.A.R.T monitoring utility called DriveScope:
https://www.micromat.com/products/drive-scope
As
casperes1996 said, it is conceivable it's caused by an AppleRAID software issue. I think that's somewhat unlikely -- I've used AppleRAID a lot on two-drive RAID-0 arrays without problems. However it's possible. From a troubleshooting standpoint you could temporarily try changing that to hardware RAID since the Elite Pro Dual supports it. It would have to be reformatted for this.
If you plan on using software RAID, I suggest SoftRAID, which is an excellent, very reliable product. For RAID 0/1 you don't need it but it's constantly maintained and improved (inc'l performance), whereas I don't think AppleRAID has been improved for a long time.
https://www.softraid.com
Yes it's paying money for functionality you already have but if you ever want higher RAID forms like RAID-5 it supports that. I've done lots of performance testing of SoftRAID in RAID-5 vs the hardware RAID on a Promise Pegasus R4, and SoftRAID was faster in execution and much faster in the rebuild or formatting phase. The host CPU overhead was minimal.