Let me know if you do it. I have the same machine, 2015 retina with 1TB fusion drive. I guess the worst thing you can do is try it, leave the fusion drive alone, boot for a bit on the external drive, like the Samsung t7 and see what happens. I've noticed the largest issue with my iMac fusion is the SLOW boot time. But after it boots and everything loads, it runs great. I rarely reboot, I run 2 external monitors, work on Teams, Mail, iMessage, Safari and Citrix workspace app all day long and it doesn't skip a beat. Since I work from home, I am a bit nervous to trust a cheap external SSD plugged in via USB to be stable.
I have 2 2017 MacBook pro's, 13", they boot EXTREMELY fast, and work great, but they aren't full time work computers for me, more part time machines for working outside my home office.