I did this for 5 years with 0 issues. From my experiences the perfect 680MX overclock is +250/+375 (MSI Afterburner), anymore and the temp starts to rise noticeably with no real performance gain. Also higher overclocks than this can give random reboots in dx11+ games, probably from drawing more power than the iMac PSU can handle.
Also use Macs Fan Control for Bootcamp, and set a static fan speed like 2250-2350rpm for the most demanding games. Your GPU temperatures should stay within the 80s (Celsius). This is with the assumption that your 680MX unit behaves similar to what mine did.
Don't forget to cap the framerate at 59 (MSI Afterburner), which reduce triple buffered vsync lag (use D3DOverrider), and avoids that the GPU works harder than it needs to (ie. avoid unnecessary GPU heat).