What I have: 27in iMac late 2014, i7, 16GB RAM, SSD, OSX 10.10.1 Wired Peripherals: Onyx Blackjack, 2 partition NAS, 2x24in Apple Cinema Displays, Anker 9 port USB 3 hub Bluetooth Peripherals: Apple Magic Mouse, Magic Trackpad, and Apple Wireless keyboard. Other: Mobile mouse app for iOS (which uses WiFi and is fully functional during the rest of these issues) The Deal: So, what is going on is my machine randomly stops responding to bluetooth devices and USB inputs. I thought it was only after sleeping but today it did it while I was using the machine. I plugged in a wired keyboard and the USB port came back to life (evidenced by the Blackjack lighting back up), although the keyboard input still did not work. This started out of nowhere. I have owned the machine for over 3 months and it just randomly started. I was still on Mavericks at the time and upgraded in hopes it would fix it. No dice! In fact, it came with a new problem. When I upgraded to Yosemite, it also started randomly ejecting my external disks, which I have found a work around for by turning off spotlight on those disks. Lame I have tried the usual fixes, disconnected and reconnected all peripherals one at a time, reset SMC, reset NVRAM/PRAM, Permission repairs, cleared caches (I use Onyx). I even tried deleting the bluetooth plist file. No love...I live 250 miles from the nearest Apple Store and really don't want to be without my machine if I can avoid it. Anybody have any ideas before I file a warranty claim?