Virtual machines are NOT necessary (in my experience).
In times past, I had a ZIP100 SCSI and was pretty good with it.
I don't own a ZIP250. I have no experience with that size.
I DO have a ZIP100 USB drive (that I picked up at a computer recyling bin!)
I have only four ZIP100 discs available, no longer in "active use", but just stored.
A few minutes ago, I powered up my 2021 MacBook Pro 14"
It has Monterey installed, NOT Ventura.
I connected the ZIP100 USB.
I tried each of the 4 ZIP100 discs I have.
First one wouldn't mount (see below).
Second one mounted right up in the finder (it was empty).
Why wouldn't the first one mount?
I connected the ZIP to my 2018 Mac Mini, which still runs Mojave.
The disk mounted.
I did a get info on it and found it was formatted in original HFS (not HFS+).
But HFS still mounted in Mojave. I reckon support for HFS was dropped somewhere between there and Monterey.
So (still on the Mini) I copied everything on that HFS disk into a folder (94mb, doesn't seem like "much" these days!), used disk utility to reformat the ZIP disc to HFS+, then copied the data back onto it.
NOW it mounts on the MBP running Monterey.
So... once I corrected the formatting problem (HFS to HFS+), all four disks now mount and are accessible on the 2021 MBP running Monterey.
Again, this is a ZIP100 USB drive.
Cannot provide info for the ZIP250 because I never owned one.
Also, don't know if there is any change re ZIP handling between Monterey and Ventura.