iOS 6.1 BETA 2

My advice from experience is:

Backup on 6.0.1 to icloud and iTunes.
Turn off icloud backup (so it does not try to backup when on 6.1)
Make a copy of your 6.0.1 backup and keep it safe (maybe on the desktop)

If you update to the beta you will still have backups from 6.0.1 should you need it. When using 6.1, you can backup in iTunes, but it will most likely backup over the prior backup on 6.0.1 (hence making a copy)

When you finally upgrade to the 6.1 GM you can indeed restore from backup using either the 6.1 beta backup or 6.0.1 backup.

If you backup to icloud with 6.1 beta then you need to restore to 6.0.1 (should there be a reason), you cannot use the 6.1 backup to restore if the device is running 6.0.1 - as It was made using 6.1 which is newer than 6.0.1

Just make sure you keep a copy of the 6.0.1 backup somewhere safe and turn off icloud backups until the GM comes out.

Hope that makes sense (a little confusing I know!)

 

Just remember, 6.1 beta 2, is indeed beta software. Things can go well for one person, but the next person have god only knows what problems. If the phone you are about to put it on is your primary phone, not a test or development platform, you could easily brick the phone, converting your phone to a very nice paper weight. If it is your primary phone I would wait till the GM is released.