This topic is being discussed in multiple threads but thought Id post what Ive done to remedy it on both mine and my wifes 4S. Some items may have not done anything but the overall result has been extremely positive. Notifications only have these running: Weather Widget Phone Messages Calendar Facebook NBC News Stock widget Mail ESPN score center The Weather channel Government alerts are both ON Use cellular Data for: Only iCloud documents is ON, all others OFF Location Services: All ON except Camera, Chrome, safari iCloud: All OFF except Contacts, Calendars, find my iPhone, my photo stream, documents & data and use cellular data Storage & backup: iCloud backup is OFF Facetime: use cellular data is OFF iTunes and App Store: all OFF Music: iTunes match is OFF Mail: All mail accounts set to fetch 15 minutes. Photos and camera: My photo stream is ON. Shared photo streams is OFF Facebook: calendar and contacts are OFF, Facebook ON After these parameters were set I full charged the phone. Once fully charged with the phone still attached to the charger, preformed a hardware reset. Battery performance is the same if not better than 5.1.1. Hope this helps others.