Zero scratches on the screen. A couple of microscopic scratches on the apple on the back, and no noticeable scratches on the rest of the back or the bezel.
When I'm out and about, I keep it in my right front jeans pocket (alone) about 75% of the time, my purse (maybe separate, maybe not) about 10% of the time, and in my bra the rest of the time. Yes, really.
I pop it into the WindowSeat when I'm in my car, since I have a dedicated hookup that charges and plays through the stereo.
And when I'm home, it's on my desk, my nightstand, or some other hard surface (but usually on a cloth or book if I remember).
I'm not completely anal, but I'm careful with my stuff, so I haven't had an issue. And I use it constantly.