Wirelessly posted (Mozilla/5.0 (Macintosh; U; Intel Mac OS X 10_6_5; en-us) AppleWebKit/533.19.4 (KHTML, like Gecko) Version/5.0.3 Safari/533.19.4) I suffer from the unresponsive iPhone home button daily. Many times it would not respond at all. This has plagued me since I jailbroke my phone. I fixed it by pressing the home button in. I remember while jailbreaking I may have pushed it too hard. Pushing it and keeping it pressed for 20 seconds has totally solved my problem. My issue was more extreme than many users who would have casual issues. Tested my phone now and not one error/problem with the button. I have activator set to restart on short hold of home button so it did reboot the phone during this. So try to hold the home button in firmly reboot and see if ti fixes your problem. If not keep trying it varying pressure on the home button.