I have a 16g 4S and intermittently people can't hear me when I make a call. If I activate the speaker then they hear me fine. I'm guessing there's only one mic and since it works with the speaker the mic is probably ok. Since the mic is likely ok I think Apple has a bug in their firmware someplace. I think I've noticed this only happens after I undock the phone from my Apple docking thing (just for power and input to a stereo). I bet it's related to undocking the phone.