Well, just when you thought things might be going OK, they throw you a curve ball. I updated my iPhone 5s to iOS10 and things went just fine. Did it over the air and had no hiccups. Went to back it up, after the update and when iTunes popped up I got a popup and the iPhone would not connect with iTunes. After restarting the iMac (Late 2006), running 10.7.5, still no luck. Plugged and unplugged the iPhone multiple times and still get the same message. The iPhone has asked multiple time whether to trust the computer or not and has been instructed to trust it. Not sure if that's related or not. The version of iTunes is older, too, so maybe that has something to do with it? It worked fine on all recent updates. Now I'm kinda stuck, because I can't even revert to the previous iOS without accessing iTunes. Any ideas would be helpful. I've run through my repertoire.